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Schmitt M, et al: Biopharmaceutical evaluation of carprofen following single intravenous, oral, and rectal doses in dogs. When tested in an in vitro equilibrium dialysis system using canine and feline plasma, cefovecin has been shown to result in an increase in the free concentration of carprofen, furosemide, doxycycline and ketoconazole in dog plasma, and in the free concentration of furosemide and ketoconazole in cat plasma. Some clinical signs were observed during field studies (n=297) which were similar for carprofen caplet- and placebo-treated dogs. 7 times the recommended total daily dose of 2 mg/lb) of carprofen. Ricketts AP, Lundy KM, Seibel SB: Evaluation of selective inhibition of canine cyclooxygenase 1 and 2 by carprofen and other nonsteroidal anti-inflammatory drugs. It has been suggested that treatment with carprofen may reduce the level of inhalant anesthetics needed. 5-9 Data also indicate that carprofen inhibits the production of osteoclast-activating factor (OAF), PGE1, and PGE2 by its inhibitory effect in prostaglandin biosynthesis. 3 In an in vitro study using canine cell cultures, carprofen demonstrated selective inhibition of COX-2 versus COX-1. Carprofen has also been shown to inhibit the release of several prostaglandins in two inflammatory cell systems: rat polymorphonuclear leukocytes (PMN) and human rheumatoid synovial cells, indicating inhibition of acute (PMN system) and chronic (synovial cell system) inflammatory reactions. Carprofen is the nonproprietary designation for a substituted carbazole, 6-chloro-α-methyl-9H-carbazole-2-acetic acid. The mean terminal half-life of carprofen is approximately 8 hours (range 4.

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